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We observed a strong association of obesity to the FTO gene, with the most significantly associated marker being rs3751812 (P = 2.01×10−8, odds ratio = 1.64).
Partitioning the explained variance onto chromosomes revealed a large contribution of Bos taurus autosome 7 not harboring any associated marker in the current study.
The key difficulty in Py-GC/MS data evaluation is recognizing the connection between the constitutive materials of the PU coatings and the sets of associated marker compounds formed by pyrolysis of these materials.
Besides identifying a real causative polymorphism directly responsible for the phenotype, allelic association may point to a polymorphism that is in close linkage disequilibrium to the associated marker.
We noted an up-regulation of differentiation associated marker genes, BMP4, HAND1, EOMES, ID2, GATA4, GATA5, ISL1 and MSX1 (Fig. 9D).
The power of this approach relies on the assumption that the previously associated marker and the causal variant(s) remain in linkage disequilibrium across populations (Fig. 3A).
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They share common characteristics with human embryonic stem cells (hESCs) with respect to morphology, pluripotency-associated marker expression and capacity to generate neurons, cardiomyocytes, and hematopoietic progenitor cells.
Similarly, another outlier under positive selection could be located in the proximity of the associated marker on 3R (ca 50 cM apart), while the other one did not appear to be linked to the second Al-associated marker.
Mab CF511 recognised the 600 kDa sialylated glycoprotein as different from previously known tumour associated-marker antigens.
Another important observation in our study was the lack of association between PARP1 and HER2 and basal-associated marker expression in breast cancer.
Nevertheless, in the presence of a pattern suggestive of an autoimmune hepatitis-associated marker, confirmation tests are indicated.
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