Fibrillation and aggregation of κ-casein, a phenomenon which has only recently been detected, might be associated with malfunctions of milk secretion and amyloidosis phenomena in the mammary glands.
Shorter infusion times were associated with malfunctions in approximately two-thirds of infusions.
The corrective properties of S5a in directing proper chain formation and prioritizing proteasome-bound substrates might be useful for enhancing protein turnover or overcoming stress conditions associated with malfunctions in the ubiquitin proteasome system.
The application of a passive Q-switch to resolve a problem with laser pulse emission associated with malfunctioning of the active Q-switch.
Missing columns are associated with malfunctioning nozzles.
Its fundamental importance in metazoan biology is underscored by evolutionary conservation and by the spectrum of mutant phenotypes associated with malfunction of Notch signaling [1], [2], [3].
Dysfunction of the mitochondria is the pathophysiological basis of a continuously growing group of heterogeneous diseases and clinical syndromes, most of them associated with malfunction of the respiratory chain [1] [3].
Indeed, several reports showed that aging and progression of diabetes are both associated to malfunction and failure of the Hsf-1 system [55], [56], suggesting loss of cell ability to respond to stress and increased susceptibility to cell damage in later stages of age-related diseases.
Several human diseases, including cancer, are found to be associated with malfunctioning of the autophagic process.
Failure to regulate this homeostasis leads to autoimmunity, which is often associated with malfunctioning T cell signaling.
In fact, a wide variety of diseases have been associated with malfunction of the ER and defective UPR signalling, including Marinesco Sjögren syndrome, a cerebellar ataxia with cataract and myopathy, caused by mutations in SIL1 that encodes a nucleotide exchange factor for BiP (66).
