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Pathophysiologically, exposure to CARDS toxin and the associated inflammatory responses in the lungs could account for the changes observed in pulmonary function after infection.
The infections and the associated inflammatory responses are the most important causes of morbidity and mortality in CF patients today.
We speculated that inducing very severe lung damage with multiple doses of elastase interfered with virus infection and associated inflammatory responses, as previously reported [ 19].
In addition, bacterial or viral infections and the associated inflammatory responses have a significant effect on HSCs and thus likely also on their niches [ 79].
Chronic infection and associated inflammatory responses lead to progressive loss of lung function and respiratory failure (Callaghan and McClean 2012; Costello et al. 2011).
The pan-sPLA2 inhibitor, indoxam, suppresses LDL modification and associated inflammatory responses (such as NF-κB activation and chemokine production) in TNFα-stimulated human endothelial cells, which express sPLA2-V [ 45].
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The persistent CMV associated inflammatory response outlined here is also notable for its magnitude.
In conclusion, we identified an unexpected role for the B7/CD28 pathway in the regulation of Th17-associated inflammatory responses.
Inhaled hydrogen gas effectively reduced VILI-associated inflammatory responses, at both a local and systemic level, via its antioxidant, anti-inflammatory and antiapoptotic effects.
Cancer-associated inflammatory responses play roles in many aspects of cancer biology including tumor initiation, progression, metastasis, and treatment.
These effects diminish critical functions of the immune system and therefore presumably attenuate atherosclerosis-associated inflammatory responses.
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