As mentioned above, each institution should assess its own CSR and associated indications since it may be different from others.
However, it is prudent to scan patients for specific associated indications such trauma, abnormal neurological signs, seizures or an uncertain history of drug ingestion.
The chart review approach not only requires the experts to have comprehensive knowledge of the administered medications and their associated indications, contraindications, and ADRs, but also demands that the human reviewer be intimately familiar with all details of the patients in order to be able to judge if a new diagnosis, sign, or symptom recorded in the notes is a potential ADR signal.
Raspberry was used for colds and flu's and health promotion, where its properties would likely provide little benefit, in addition to the usually associated indication as a uterine tonic in preparation for labor [ 34].
These proteins, examples of drugs and associated therapeutic indications are detailed in section 4 in Supplementary information S1 (notes).
However, smoking is also associated with indications for kidney transplant, so that confounding by smoking history is also difficult to rule out in this scenario (Wen et al, 2008).
The following factors were associated with indications for transfusions: lower gestational age, higher SNAPPE II score, presence of apnea, pulmonary hemorrhage, clinical sepsis, moderate/severe intraventricular hemorrhage, necrotizing enterocolitis, bronchopulmonary dysplasia, umbilical catheter use, parenteral nutrition, prolonged hospital stay and center.
Higher levels of multimorbidity among the patients were to a higher extent associated with indication for treatment (Table 4).
Associating alternative indications with approved drugs is a rapid way to find potential cancer drug therapies (repositioned drugs) and target molecules (repositioned targets).
Greater, but not significant, increased risk was associated with maternal indications for operative delivery compared with fetal indications.
In this study, we have established a database we call "PharmDB" which integrates data associated with disease indications, drug development, and associated proteins, and known interactions extracted from various established databases.
