Sentence examples for associated inactivation of from inspiring English sources

POR deletion and the associated inactivation of hepatic P450 function leads to accumulation of dietary fatty acids in the liver, in the form of triacylglycerols of unsaturated fatty acids, leading to organ enlargement and increased P450 expression, in the case of CYP2B, CYP2C and CYP7A1 via a CAR-dependent signalling pathway.

The DNA hypermethylation-associated inactivation of the TBXA2R, F2RL2, SORBS3 and SPTBN4 genes discovered here in samples of Alzheimer's disease could provide additional clues to understand the pathology of the disease.

Thus, it is important for future studies to analyze DNA methylation patterns of the PARP1 promoter in the DNA methylation-associated inactivation of the BRCA1 gene in ovarian cancer.

Thus, the observed DNA methylation-associated inactivation of SPTBN4 could relate to both tau hyperphosphorylation and an increase in the amyloidic processing of amyloid precursor protein, the two main hallmarks of Alzheimer's disease.

Methylation-associated inactivation of RASSF1A has been frequently observed in several human malignancies including sporadic CRC [33], [34], [35], [36], [37].

As expected from the results of Table 1, most chromosomal regions associated with changes in expression levels actually correspond to gene inactivation patterns in cancer cells (373 up-regulated versus 744 down-regulated hits), striking examples of cancer-associated inactivation of gene expression being chromosome 17 and chromosome 3.

Eighty percent hereditary breast cancers are associated with inactivation of breast cancer-associated genes (BRCA) type 1 and 2 by sequential mutations.

This effect was associated with inactivation of Wnt/β-catenin pathway in differentiating HFSC by both DPC-conditioned media.

Therefore, their production is dependent upon the use of high containment facilities and their deployment carries the risks associated with inactivation of "live" FMDV.

During sepsis, hepatic apoptosis occurred, which is associated with inactivation of PKCα and elevation of tumor necrosis factor-alpha (TNFα), an apoptosis trigger.

They are associated with inactivation of hSNF5/INI1 gene on chromosome 22q11.2.