Sentence examples for associated immune suppression from inspiring English sources
None these patients had HIV and few received corticosteroids indicating the influenza A associated immune suppression may be sufficient for the development of invasive pulmonary aspergillosis.
Accordingly, the observed reduction in IL-6 and TNF- α levels in the TB-SNC group might partly account for the reduced inflammatory state and the improved functional aspects of the catabolism associated immune suppression.
HIV infection and the associated immune suppression is a major risk factor for the development of active TB in those who acquire new M. tuberculosis infection or have latent M. tuberculosis infection.
Although T cell hyporesponsiveness associated with down-regulated CD3ζ chain has been observed in a variety of disease manifestation, the molecular mechanisms leading to the down-regulation of one of the main the signalling chains of the TCR and the associated immune suppression are not well defined.
In addition, there are other barriers that limit CAR T treatment in solid tumors, among which the most important issues are tumor-suppressive microenvironments, tumor-associated immune suppression, and the sub-optimal quality and quantity of the infused CAR T cells.
In this review, we focus on the primary challenges and strategies to design safe and effective CAR T cells, including using novel cutting-edge technologies for CAR and vector designs to increase both the safety and efficacy, further T cell modification to overcome the tumor-associated immune suppression, and using gene editing technologies to generate universal CAR T cells.
Chronic Lymphocytic Leukemia (CLL) is immunophenotypically defined as a malignancy of CD5/CD19/CD23 positive, CD20 and Ig dim B cells that manifests with bone marrow failure, lymphadenopathy and infections as a consequence of disease-associated immune suppression.
It is hypothesized that these immunomodulating properties augment systemic antitumor effects and contribute to a reduction of chemotherapy-associated immune suppression.
A possible explanation for the tumor-associated immune suppression is that aberrant expression of B7-H1 might downregulate tumor-specific T cell response by inducing T cell anergy or apoptosis.
