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This paper explores the role of BDNF in this process, using the effect of a Trk antagonist (K252a) on the labelling of progenitor cells with the mitosis marker Ki67 and the associated expression of pCREB and Wnt3a.
A vital role in tumor angiogenesis is played by the Vascular Endothelial Growth Factor (VEGF), but the associated expression of both VEGF and its receptors by most advanced stage melanomas also suggests the possibility of an autocrine loop within the melanoma cells.
The associated expression of Maspin and Bax might delay tumor progression in IHCCA.
Associated expression of genes may indicate a common role in physiological processes or pathways.
The associated expression of leptin and IL-1 has been described in several pathological situations.
The associated expression of Bax in Maspin positive sections might imply an activation of the apoptotic pathway.
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Recently, it was shown that stromal cell-associated expression of KLK6 is an indicator of poor prognosis in ovarian cancer patients [8].
Additionally, pFap vaccination reduced stroma-associated expression of pro-angiogenesis factors and effectively suppressed tumor angiogenesis and lymphangiogenesis.
We also validated the senescence-associated expression of several miRNAs with less abundant evidence for a senescence-associated function.
S-MAP tests for significant stemness-associated expression of a particular gene or module by computing three scores – recurrence, specificity, and diversity (Figure 1).
Previous work has shown HFS-LTP-associated expression of zif268 in new neurons of at least 2 weeks of age [31].
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