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The threat of the high rate of antimicrobial drug use in food-production animals and associated emergence of drug resistance in zoonotic pathogens has been recognized for decades.
A Bautin bifurcation (B) marks the point at which the Hopf bifurcation changes from supercritical to subcritical, and also the associated emergence of the curve of saddle-node of periodic orbits (SNp).
However, the delay for EMT induction and the associated emergence of H-RasV12-transformed CD24− cells suggests that additional events are required.
Multiple studies have been undertaken to tackle the molecular mechanisms, underlying the dual agonist/antagonist action of SERMs and the associated emergence of drug resistance.
This is the first time a proposal has been made to withdraw an approval for an antimicrobial used in agriculture because of associated emergence of resistance in humans.
They showed that the evolutionary rate and associated emergence of a diversity of chemoresistant lineages is a major determinant in the success or failure of multiple drugs vs a single one.
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The major goal of this study was to document antimicrobial drug resistance among historical bacteria from humans and animals to associate emergence of resistance with approval of new antimicrobial classes.
Whether one type of carbapenem is more associated with emergence of resistance should be further explored.
Using antibiotics for less than 4 days was not significantly associated with emergence of resistance (Table 2).
Evidence accumulated from etching (and as shown in a subsequent paper, describing microindentation studies) strongly suggests that the observed etch pits are associated with emergence of dislocations.
Wild-caught AGS readily hibernate under laboratory conditions and provide a model of pronounced adult synaptic plasticity associated with emergence from hibernation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com