Sentence examples for associated deregulation of from inspiring English sources

Reorganisation of the actin cytoskeleton and the associated deregulation of ECM adhesion are known to be an intrinsic property of arthritic synovial fibroblasts.

Increased ribosome number and associated deregulation of protein synthesis could be one step in the progression toward tissue growth, proliferation, and ultimately malignancy (Ruggero and Pandolfi 2003; Shiao et al. 2005).

The use of PB for the detection of MRD is debatable because subtle leukaemia-associated deregulation of gene expression extends to many other molecules normally expressed during B-cell differentiation [ 33, 34].

This indicates that in this model, DNA methylation changes are not the major regulatory factor of the senescence-associated deregulation of transcription, which is in contrast to the proposed heterochromatin-loss model of aging [ 42].

Alternatively, does one observe preferential enrichment of specific TF motifs among the sites that acquire age-associated DNAm changes, which would then point to the importance of specific TFs in mediating this age-associated deregulation of DNAm patterns, analogous to the TF-mediated redistribution of DNAm patterns one observes in response to stem cell differentiation and disease (87, 88).

In particular, we wanted to investigate the function of the cell-cycle regulator cyclin E in the genetic interaction between FBW7 and BUBR1 given that the CIN phenotype in FBW7 knockout HCT116 cells was previously associated with the deregulation of this FBW7-associated substrate (Rajagopalan et al. 2004).

Therefore, the eye phenotype that we observe might be explained by enhanced membrane internalization in the EndoAA66W mutant, leading to reduced activity of the EGFR-associated pathway and deregulation of apoptosis.

Caspase 3-mediated axonopathy may involve axonal transport deregulation, proteolysis of cytoskeletal components such as spectrin and microtubule-associated Tau and/or deregulation of downstream proteases (Gamblin et al., 2003; Reeves et al., 2010; Westphal et al., 2010).

Taking all those findings together, we consider that the deregulation of FBN1-associated network could be crucial to understand the cardiovascular characteristics associated with DS as it is in other syndromes (Henrichsen et al., 2011; Mohamed et al., 2009).

Here we studied the possibility that DNA methylation at Notch pathway gene promoters and/or deregulation of Notch-associated microRNAs contribute to activate Notch in mycosis fungoides (MF).

52, 53 Deregulation of tumor-associated miRNA, proteins and signal transduction pathways is involved in breast cancer chemoresistance.