Thus, endothelin receptors can be considered as a potential pharmacological target for the management of experimental diabetes induced vascular endothelial dysfunction and associated dementia.
The study was designed to investigate the efficacy of bosentan a dual endothelin (ETA and ETB) receptor antagonist in experimental diabetes induced vascular endothelial dysfunction and associated dementia.
An approach based on prodrug synthesis and encapsulation into PEGylated nanocarriers was proposed and applied to didanosine, a nucleosidic analogue used to treat HIV-1 associated dementia.
There are indications that MMP-2 might play a role in the pathogenesis of AIDS-related Kaposi's sarcoma [83], [84] or HIV-1 associated dementia [85] [87].
Under the social model only a few participants associated dementia with curses or witchcraft.
HIV dementia, also termed HIV associated dementia or AIDS dementia complex, is a subcortical dementia which is characterised by a combination of cognitive/behavioural and motor dysfunction.
During interviews, six PWD and 18 caregivers associated dementia with other diseases like high blood pressure, stroke, diabetes and malaria.
Its clinical severity includes asymptomatic neurocognitive impairment (ANI), mild neurocognitive disorder (MND), and more severe HIV associated dementia (HAD) [ 2].
Patients with diagnostic Read codes of dementia subtypes including Lewy Body dementia, frontotemporal dementia and HIV associated dementia were also excluded as they have potentially different aetiologies.
IP-10 has been detected in the CSF of individuals with HIV-1 infection [ 25] and in the astrocytes in brains of individuals with HIV associated dementia [ 26].
One of these, clusterin (Gene symbol CLU), was previously reported to be reduced in patients with HIV associated dementia relative to non-demented control samples [ 35].
