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Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
To explore this possibility, we examined the relationship between chromosome size and the extent of centromere-associated clustering of Rec8, an evolutionary conserved meiotic subunit of the multiprotein cohesin complex.
Adult GHD syndrome is associated with clustering of adverse cardiovascular (CV) risk factors such as abnormal body composition, dyslipidemia, insulin resistance and abnormal haemostatic factors.
Central obesity is associated with clustering of cardiovascular risk factors.
Fibrillar Aβ plaques are associated with clustering of activated microglia and astrocytes.
Mitochondrial dysfunction in pink1 mutants is associated with clustering of these organelles in the indirect flight muscle.
In addition, pathogen-specific factors were associated with clustering of MDR TB cases, independent of traditional clinical and demographic risk factors.
Accumulation of fat preferentially in the abdominal cavity is frequently associated with clustering of metabolic and inflammatory alterations, often referred to as metabolic syndrome (MetS) [ 1, 2].
A study conducted in Brazil had also reported that higher age and low socio-economic status was associated with clustering of NCD risk factors (31).
Studies in adults and also in adolescents reveal that physical activity (PA) - a modifiable lifestyle factor - is strongly associated with clustering of metabolic syndrome components [ 13- 18].
Lower compliance with preventive screening or medical check-ups was associated with clustering of other risky behaviours, [ 23] or with an 'inactive' cluster among a sample of women [ 25].
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