Due to the genetic relationship to humans, porcine stem cells are a very important model system to investigate cell differentiation, associated cell signaling pathways, and cell fate.
Such rewiring of gene expression, associated with cell fate decisions, is governed by chromatin remodeling.
In mammalian skin, canonical Wnt/β-catenin signalling has strongly been associated with cell fate determination by stem and progenitor cells (Blanpain and Fuchs, 2006; Niemann, 2006).
Figure 2C presents the profiles associated with cell fate commitment and other related terms or pathways, as Notch, Wnt, or Somitogenesis terms.
Gene Ontology (GO -term analysis of the GO -termwnregulanalysisn esg RNAi yielded many significantly enriched Gofthems associated with cell fate specification, cell sigenesng, andownregulatednd tracheal development (SuponesgntaRNAiable S3).
Interestingly, though most of the genes present in this peak were associated with cell fate determination in embryos, such evidence was mostly missing for the larvae peripheral nervous system (PNS).
85 Many of the signaling pathways related to cellular stress responses such as the UPR and autophagy appear to be associated with cell fate decisions in tumors growing under stressful conditions.
Using knockout and in utero electroporation mouse models, we report a key role for the microtubule-associated protein 600 (p600) in the regulation of spindle orientation in aNPs, a cellular event that has been associated with cell fate and neurogenesis.
In mammalian preimplantation embryos, cell division timing appeared to associate with cell fate choices (Chazaud and Yamanaka, 2016; Zernicka-Goetz, 2006).
Thus, switching modes of β-catenin function are associated with consecutive cell fate specification and stage-specific progenitor proliferation.
