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The changes are greater in the distal colon and appear particularly associated with the sensing of genomic damage, associated cell cycle arrest and a cellular switch towards the induction of apoptosis.
This observation suggested a link between Yca1p and G1/S associated cell cycle dynamics.
Since similar results were not observed in tel1 deletion mutants, the persistent checkpoint activation, the associated cell cycle arrest and the bleomycin sensitivity might be mainly dependent on MEC1.
A representative example of each compound class and their associated cell cycle profiles are indicated in Figures 1f h.
In keeping with the lack of effect of growth factors or PI-103 on cell cycle progression, there was very little change in the expression of cyclin D1 and associated cell cycle control proteins with the different treatments.
Congruent with BPA-induced increase in positively associated cell cycle proteins, significant accumulation of the fork protein PCNA (P = 0.0000) and the replication origin helicase MCM2 (P = 0.0000) was observed within DNA-bound fractions of BPA-exposed HRBEC lysates.
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In oral mucositis, epithelial proliferation is nearly halted due to the presumed combination of TGFβ-mediated growth inhibition and DNA damage-associated cell cycle arrest after radiation.
In this review, we discuss molecular mechanisms of hERG-associated cell cycle regulation and cell death.
PMA induced a dramatic increase of p21Waf1/Cip1 mRNA expression in U937 cells which is consistent with differentiation-associated cell cycle arrest.
Both cisplatin and doxorubicin suppressed tumor cells by activating P21-associated cell cycle arrest and caspase-3 dependent apoptosis via caspase-8 or caspase-9 pathways [ 34, 35].
Thus, DHA may exert its negative effect on growth of tumor cells by inhibiting activation and expression of G1-associated cell cycle regulatory proteins [ 33].
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