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Interestingly, Prdm proteins associate with a wide range of chromatin-remodelling enzymes and also act predominantly as transcription repressors [16], [40] [44].
Collectively, these studies provide novel insights into how Sox2 is able to associate with a wide array of nuclear proteins that control gene transcription.
Interestingly, the latter studies indicate that Sox2, Oct4 and Nanog associate with a wide array of co-activators and co-repressors.
This is consistent with the observation that CCR5 and its ligands associate with a wide array of immunological responses relevant to HIV-AIDS pathogenesis, including cell-mediated immunity, T cell regeneration, activation-induced cell death, and formation of the immunological synapse [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90].
Rb family proteins associate with a wide range of chromatin remodeling proteins forming transcriptional repressor complexes [ 28].
The presence of antinuclear antibodies (ANA) is associated with a wide range of ANA-associated autoimmune rheumatic diseases (AARD).
The presence of antinuclear antibodies (ANA) directed against intracellular antigens is associated with a wide range of disorders, including ANA-associated autoimmune rheumatic diseases (AARD).
In addition, the associated variants are usually not disease specific but have been associated with a wide range of disorders.
Being overweight, particularly being obese, is associated with a wide variety of medical problems, like diabetes and liver disease.
