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The Hsp90 is a dimer of the ∼90 kDa subunits that associate via a C-terminal dimerization domain.
The Act1 and IL-17 receptors directly associate via a homotypic interaction and IL-17.
Dimers on opposing membranes can associate via a head-to-head interaction to form tetramers with moderate affinity consistent with reversible intercellular associations.
Kinases frequently act through dimerization, including BRAF and CRAF (10, 36), and crystal structures of MEK predict MEK1 and MEK2 self associate via a homodimerization interface to form stable dimers (37).
Most of the positive signalling receptors from these receptor families associate via a characteristic positively charged amino acid in their transmembrane domain with the ITAM-containing adaptor DAP12 [ 49, 50].
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The observation that RIPK3 ablation rescues embryonic lethality in mice deficient in caspase-8 or Fas-associated-protein-via-a-death-domain demonstrates the crucial role of this apoptotic platform in the negative control of necroptosis during development.
Together, these results indicate that CDC25B and Ctn proteins are within very close proximity at the centrosome and can be found in the same protein complex, they are likely to associate via an indirect mechanism.
In her recent book, Wolf has revealed that, in women, the brain and the vagina are directly associated via a number of pathways, and a woman's consciousness and mental ability are dependent on the functioning of her vagina.
They are associated via a C-terminal 4-helix bundle (called tetramerization domain) whose stability is ensured by the interaction of leucine zipper motifs.
The crystal structure determination of 1 reveals that the two molecules are associated via a carboxylic acid-pyridine hydrogen bond, while the nic forms a centrosymmetric R22 8) dimer to ultimately form a ribbon architecture which is compared to other known cocrystals of nic.
Binding studies showed that beta 2-syntrophin and MAST205/SAST associated via a PDZ-PDZ domain interaction.
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