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β-Barrel pore-forming toxins contain amphipatic β-hairpin forming sequences that associate to form a β-barrel when the toxin is oligomerized, which inserts itself into the lipid bilayer, resulting in pore formation [42].
"People will associate to form a bigger, stronger society in many ways which will be random," he said.
Thus, two catalytic domains of CA IX associate to form a dimer, which is stabilized by the formation of an intermolecular disulfide bond.
Thus, we obtained a model that is consistent with the biochemical knowledge that the KEKE motifs of Uch37 and of Rpn13C associate to form a heterodimer (Fig. 5B and 5C).
However, the NTE itself was not sufficient for oligomerization suggesting that multiple structural features of HMT-1 must associate to form a functional transporter.
IL-12R has been shown to consist of at least two distinct subunits, B1 and B2, that associate to form a high-affinity IL-12R complex expressed on activated T- and NK-cells (17,18).
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Circular dichroism spectroscopy, analytical ultracentrifugation, and thermal unfolding studies indicate that the A and B peptides specifically associate to form an A2B2 heterotetramer.
The assembly of the proteasome is a complex process due to the number of subunits that must associate to form an active complex.
In PABP, the RRM domains of a single subunit associate to form an extended β-platform capable of binding an elongated, contiguous nucleic acid.
Neither the 50-nor the 30-kDa fragment, expressed in vitro in COS cells, have been demonstrated to possess GALC activity, an indication that the entire structure is probably necessary for enzymatic activity and that fragments expressed separately cannot subsequently associate to form an active enzyme [ Chen et al., 1993; Chen and Wenger, 1993; Sakai et al., 1994, Nagano et al. 1998].
Whereas eukaryotic type II topos, such as human or yeast topo II, are large single-subunit enzymes (∼170 kDa) that are active as homodimers, prokaryotic enzymes, such as gyrase and its close relative topo IV, are composed of two subunits: A and B in the case of gyrase, which associate to form an A2B2 complex in the active enzyme (Champoux 2001).
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