Exact(1)
The availability of a sufficiently dense single-nucleotide polymorphism (SNP) map for a species provides a resource which enables the power of automated high-throughput genotyping to associate regions of the genome to hereditary diseases, quantitative traits, and other phenotypes.
Similar(59)
Carla Caro Associate Region Director Pamela Perricone Region Director Westchester East Putnam Region PTA.
Having found no evidence of association with positivity for ZnT8A in the type 1 diabetes associated regions, the search was extended genome wide.
Outside of the HLA, no evidence of association with positivity for ZnT8A was obtained in the type 1 diabetes associated regions with the British cases (p > 0.03).
The linkage analysis and LDLA methodologies yielded different results, although some significantly associated regions were common to both procedures.
We predict transmembrane and peripherally associated regions from genomic sequence and position peptides and protein structures relative to the bilayer (available at http://www.degradolab.org/ez).
We were able to replicate the results in five of the six genes tested, and refined the cis- associated regions to a small number of variants.
SNPs in GWAS identified trait associated regions.
Figure 7 provides details of four strongly associated regions.
The next most strongly associated regions were at 3q23, 4p15, 6p22.3, and 18q12.1 (Table 2).
The connection results highlighted notable biological functions for sets of genes within BP-associated regions.
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