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Furthermore, a wide variety of signaling proteins, amongst them the epidermal growth factor receptor, were demonstrated to associate directly to actin (den Hartigh et al. 1992; Diakonova et al. 1995; Payrastre et al. 1991).
The actin cytoskeleton has been demonstrated to play a key role in signal transduction, and different signaling proteins have been shown to associate directly to actin (Payrastre et al. 1991; Moes et al. 2011).
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If the opinion words are associated directly to the target domain, while by passing its feature, a lot of valuable information is missed.
Very general chemical concepts (non-structural or non-specific chemical nouns), adjectives, verbs and other terms (reactions, enzymes) that cannot be associated directly to a chemical structure were excluded from the annotation process.
In the SSDDEMANDED determination, the above formula ignores curved areas of both horizontal and vertical alignment, since, on one hand, the portion of friction provided in the longitudinal direction, assigned to serve the braking process, is associated directly to the friction demanded laterally [22], and on the other, the grade values involved in vertical curves are variable.
Consequently, FARO enables exogenous factors to be associated directly to genotypes and as such unites bottom-up and top-down analytical approaches in a single association scheme.
Taken together, PG4 DNA co-occurrence with SES is independently significant in at least three cases but must be considered with the caveat that some of these co-occurrences appear significant in controls also and therefore may or may not be associated directly to structure.
Not only is atherosclerosis considered to be an inflammatory process with increased serum levels of TNFα present in patients with atherothrombotic diseases [ 13, 14], but TNFα has been associated directly to endothelial dysfunction by mediating NF-κB translocation, increasing production of reactive oxygen species, and affecting endothelial nitric oxide synthase expression [ 15- 17].
The approach offers a new dimension to the existing strategies of databases that associate structure directly to known toxicity features through training (e.g. DEREK and TOPKAT [22] and the OECD Toolbox (www.oecd.org).org
Pairs of concave molecules associate directly in bowl-to-bowl fashion and enclose an accessible supramolecular cavity of 190 Å3 hosting one water and three ethanol molecules.
To test whether Cav-3 and the triadins are able to associate directly, we studied their association in the L6 rat muscle cell line that does not express the known CRC proteins but expresses Cav-3.
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