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Using exogenous nucleophiles and synthetic methylphosphonate or 5′-thiolate substrates, we decipher that Trp330 also assists in the activation of the scissile phosphate and the departure of the 5′-hydroxyl leaving group.
NPR1 assists in the activation of programmed cell death, acting as a negative regulator (Caarls et al. 2015).
It can be postulated that, in our case, the lanthanum zirconate assists in the activation of CO2 to form adsorbed carbonate species.
They proposed that the basic nature of La2O3 assists in the activation of CO2 in the presence of surface CH x species on the metal or the metal support interface.
Since Hsp90α has been shown to activate other extracellular proteins [12], [47], it would be interesting to determine if this activation complex exists in normal cells as well as cancer cells and if it assists in the activation of other extracellular client proteins.
Once released from the exosomes, extracellular hsp90α assists in the activation of pro-MMP2 as well as plasminogen.
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This supports our hypothesis that extracellular Hsp90α functions with co-chaperones to assist in the activation of MMP-2 and can do so independently of ATP.
Thus, B cells can act as highly efficient antigen presenting cells, which assist in the activation of autoreactive T cells.
Previous data from our lab indicated that extracellular hsp90α increases cancer cell invasion by assisting in the activation of MMP-2 [ 2].
Several scenarios exist; Lys ubiquitination could act as a scaffold driving CIITA nuclear localization where ERK1/2 then binds and phosphorylates CIITA or Lys ubiquitination could be assisting in the activation of ERK1/2, as has been seen with other kinases, as is the case with protein kinase B (Akt) [ 42].
Therefore PHEX may also assist in decreasing the activation of cathepsin B. Previous studies have shown that the post translational modification of the MEPE-ASARM peptide is key to its functional role.
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