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Computational medicinal chemistry supports drug discovery by designing and identifying new drug-like chemical entities, predicting the properties and pharmacological activities of molecules, and assisting in the optimization of lead structures.
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The experimental data were used to build a two-dimensional model in COMSOL Multiphysics, in order to assist in the optimization of the various system components for the design of the next prototype.
The results obtained from this study provide a fundamental understanding of the process mechanics for cutting with realistic cutting tool edges and may assist in the optimization of tool edge design.
By comparing the current sample-based scouting (where no symptoms were found even if they were present in the orchards) and the positive FireFight risk prediction in the areas where disease symptoms were actually found, we can conclude that FireFight can assist in the optimization of scouting efforts.
Studies of these properties, and attempts to quantify how they relate to one another in the subsurface, can greatly assist in the optimization and maintenance of geothermal resources (e.g., Gupta and Sukanta [2006]; DiPippo [2008]; Grant and Bixley [2011]).
With a view to the future, pharmacogenomics and non-genetic biomarkers may assist in the optimization and individualization of ADHD pharmacotherapy, although this is not yet possible [ 10, 19, 34, 44, 50, 89].
Further molecular and clinicophatological characterization of quadruple WT GIST will help to determine their prognosis as well as assist in the optimization of medical management, including clinical test of novel therapies.
The structures of FTase inhibitor complexes are assisting in the design and optimization of cancer chemotherapeutics agents.
However, when the increased requirements in the 5G networks are considered, especially those in the EDHs, as well as the conflict between these requirements, it is a good idea that the user application demands in the cells can assist in the resource optimization process by defining the requirement planes for their connections.
MSC assisted in developing the optimization methods and finalizing the manuscript.
Assisting in the preservation of materials.
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