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The United Kingdom Medical Research Council recently proposed a framework for the development and evaluation of randomized control trials for complex interventions where theory is viewed as valuable in assisting hypothesis development and steering decisions on strategic design issues [ 22].
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Therefore, the hypergraph-based model can assist hypothesis formulation for the molecular pathogenesis of cancer.
KB and AO assisted with hypothesis generation, study design, data interpretation, and editing of the manuscript.
Despite these draw backs, we feel it has merit to assist with hypothesis generation, power calculations for randomized controlled trials and to guide clinical practice whilst definitive studies are conducted.
DJJW conceived of the study hypothesis, assisted with experimental design and data interpretation, and wrote the manuscript with editorial assistance from AH and SMcF.
With more information such as TF-target data and PPI data accumulated in the future, our approach will further assist in biological hypothesis generating and facilitate greater understanding of specific biological processes.
From the point of view of the development of this incipient Act, as well as on the potential impact in the population's health, to carry out studies which provides relevant information or which might assist to create hypothesis for the continuity of lines of research is an unavoidable need for the design of health and social policies in the next few years.
Such analysis can assist in producing hypotheses that can explain how the kinome is involved in the maintenance of different cellular states and can be manipulated to modulate cells towards a desired phenotype.
Epidemiologic criteria, such as those proposed by Hill [ 35], for assessing if the relationship between predictor and outcome variables is potentially causal can be especially helpful to assist in formulating hypotheses.
CEJ assisted in generating original hypothesis, interpreting experimental results and manuscript preparation.
Incorporating further analysis in a larger series with longer follow-up is most likely to assist in qualifying this hypothesis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com