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They can assist tissue reconstruction through specific differentiation and secretion of various bioactive macromolecules.
Although current bioinspired materials are mainly developed to assist tissue repair or engineer bone tissues, such materials could nevertheless be applied to model various skeletal diseases in vitro.
Our results elucidated the underlying mechanism accounting for chitosan morphogenetic effects on LG, and also proposed promising approaches with chitosan to assist tissue structure formation of the LG.
Synthetic biomaterials that stimulate endogenous cells without the need for biologics to assist tissue repair could circumvent limitations associated with conventional tissue engineering approaches, including ex vivo cell processing and laborious efforts, thereby accelerating the translational aspects of regenerative medicine.
Furthermore, since this artificial ECM should disappear through absorption into the body after implantation and when the new tissue is regenerated, it is preferable that materials for the matrix are prepared from biodegradable polymers to assist tissue regeneration.
The results indicate that hMSCs used in this study can serve as a trophic factor-producing source that may assist tissue repair in the injured spinal cord.
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Absorbable metals are expected to corrode gradually in vivo by generating an appropriate host response and then dissolve completely upon assisting tissue healing (Zheng et al. 2014).
In view of this, we have proposed here a computer assisted tissue classification methodology using fuzzy divergence based CW region segmentation and statistical machine learning techniques.
The aim of this paper was to develop a computer assisted tissue classification (granulation, necrotic, and slough) scheme for chronic wound (CW) evaluation using medical image processing and statistical machine learning techniques.
Yet it is unclear whether a scaffold would be required to assist in tissue regeneration or whether the in vivo tissue niche and/or local cells alone are sufficient to stimulate appropriate MSC differentiation.
After tissue damage, inflammatory cells infiltrate tissues, which, along with injured cells, produce inflammatory cytokines and other mediators that either exacerbate damage or assist in tissue repair [ 35, 41, 42].
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