In order to provide missing structural information on the substrate complexes of NaMN AT and to assist structure-based design of specific inhibitors for antibacterial discovery, we have determined the crystal structure of NaMN AT from Pseudomonas aeruginosa in three distinct states, i.e. the NaMN-bound form at 1.7 Å resolution and ATP-bound form at 2.0 Å as well as its apo-form at 2.0 Å.
Designing and simulation of the wavelength response of 1 × 2 splitter using Tapered and MMI assisted structure.
Future directions include extending the assisted structure drawing to uniquely represent more metabolites, such as acyl carrier protein-associated fatty acids.
The low missing data values may also be attributed to our administration method (computer assisted structured personal interview).
Currently, we are conducting a study to further compare the computer assisted structured personal interview to the paper/pencil administration of the survey in nursing homes.
Computational fluid dynamics (CFD) simulation was conducted to assist the structure design and discuss the relative mechanism.
Our results elucidated the underlying mechanism accounting for chitosan morphogenetic effects on LG, and also proposed promising approaches with chitosan to assist tissue structure formation of the LG.
The complication associated with dynamical effects is that the transform from intensity to scattering power is less transparent, although this prior knowledge could assist in structure determination.
Alignment of molecules with respect to an applied magnetic field is well-known in the solution NMR of biomolecules, where it is used to assist molecular structure determination.
Coevolution patterns derived from multiple sequence alignments (MSAs) provide valuable constraints that assist in structure prediction (Marks et al., 2011, 2012; Morcos et al., 2011; Weigt et al., 2009).
Our method can be used to assist crystal structure determination e.g. by identifying tentative metal ion sites to be further validated by comparison with experimental data or to propose metal positions for structural models that lack coordinates of cations, e.g. RNA structures determined by NMR spectroscopy (Shen et al., 1995) or theoretical models.
