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It has the advantage of allowing usual-care allocation of clients and would provide an estimate of the ICC which would assist sample size planning in a larger-scale subsequent trial, if judged to be feasible and valuable.
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Given that the TTO exercise can be difficult for some interviewees and limited relevant data were available to assist with sample size estimation, 16 initial interviews were conducted.
In addition, given the lack of information about the likely size of the intra-class correlation coefficient (ICC), one intention of this study is to estimate this statistic to assist in sample size calculation for a larger subsequent effectiveness trial [ 20].
Landon Myer assisted with sample size calculations and other statistical queries prior to commencing the project.
Staff of the CARF assisted sample preparation.
To assist in setting sample size and for filter quality evaluation, the Cramer Rao bound is used.
The number of children chosen for this study was to assist in informing sample size determination for a larger multicentre trial.
Prof Carl Lombard, the head of biostatistics at the SA Medical Research Council, assisted with the sample size calculation and design of the analysis.
These estimates are important to help interpretation of change scores and to assist in determining sample sizes necessary for future clinical studies.
To assist in achieving this sample size, participants will be offered flexible appointment times.
To assist in achieving this sample size, participants will be offered reimbursement of travel expenses and flexible appointment times and locations.
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