Among the 6.2 million open reading frames (ORFs) from all 1015 complete genomes used in this study, 38.9% of the ORFs are fully assigned, a further 22.4% of the ORFs have partial domain coverage and 38.7% of the ORFs have no coverage at all.
The trial involved 5,187 patients who had already received tamoxifen for 5 years and then were randomly assigned to a further 5 years' therapy with either letrozole or placebo.
Upon returning to Australia, Hassett's men were assigned to play a further six first-class matches against the state teams.
If a sample classified according to the LP type, we then assigned it to a further LP subtype using the nearest centroid rule against the correlation scores computed from the individual LP subtype-specific centroids.
To assign sequences into OTUs, a further neighbor-clustering algorithm was employed using the cluster command in MOTHUR, with 97% sequence similarity as the designated cutoff.
Those assigned to maintenance received a further six cycles of CVM after induction.
DOI: http://dx.doi.org/10.7554/eLife.03100.003 Comparisons to public databases resulted in 178 GCxGC/TOFMS metabolite peaks that could be assigned a structural identity, and a further 62 peaks that could be assigned to a metabolite class.
The majority of the carcinomas were high-grade serous adenocarcinoma (33 out of 40, 82.5%), with the remaining samples comprising low-grade serous cystadenocarcinoma (2 out of 40, 5%), endometrioid and mucinous type (1 out of 40 each, 2.5%) and a further group assigned serous carcinoma (2 out of 40, 5%), which were post-chemotherapy samples.
Our group has therefore initiated a phase III trial in which non-responders to two cycles of docetaxel, doxorubicin, and cyclophosphamide are being randomly assigned to either continuation for a further four cycles or to four cycles of a non-cross-resistant regimen consisting of vinorelbine and capecitabine [ 29].
In another pilot trial, 133 patients with large (> 3 cm) or locally advanced tumours and a clinical response to four cycles of cyclophosphamide, vincristine, doxorubicin and prednisolone (CVAP) were randomly assigned either to continue for a further four cycles with CVAP or to four cycles of docetaxel.
