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Thus, Congressional districts with large numbers of elderly or poor people often receive large amounts of federal money, through Social Security, Medicare and Medicaid, regardless of whether lawmakers from those districts have influence by virtue of their seniority and committee assignments, the study said.
In addition if patients and/or investigators had been blinded to treatment assignments, the study would have been further strengthened; however as in most typhoid trials, it was not possible to do this due to the difference in dosing schedule for the two drugs being compared.
In addition to the original treatment assignments, the study protocol included treatment adjustments at week 16 based on patients' improvement in the total back pain score and morning stiffness (ie, early escape) that included crossover from placebo to active treatment or dose escalation from 50 to 100 mg.
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Prior to treatment assignment, the study rheumatologist (WH) assesses the presence and severity of the knee joint abnormalities relevant to knee OA and safe participation in the study, including ligamentous laxity, meniscal abnormalities, flexion contractures, alignment abnormalities and surgical scars.
The patients and evaluators were blinded to the group assignments throughout the study.
Study patients, principal investigators and study site personnel remain blinded to all randomization assignments throughout the study.
All outcome assessment personnel were purposefully kept blinded to the children's group assignments throughout the study.
Data will be analysed at the conclusion of data collection by a statistician who is blinded to the group assignments of the study.
The patients, investigators, and all other clinical research and laboratory personnel were blinded to the randomized assignments throughout the study period.
The investigators, all other site personnel (except for the pharmacist preparing study drug), and all subjects remained blinded to subject treatment assignments throughout the study.
We performed a spatio-temporal reanalysis of 5 years of field data and parentage assignments from the study of Ringler et al. (2013) on TT in a natural population of A. femoralis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com