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The denominator of Equation 1 is the normalization constant that represents the sum of the product of the likelihood and the prior over all possible assignments of interaction variables.
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Main aspects in the assignment of interactions between ligands and putative targets involve the amino acid composition of the binding site, evolutionary conservation and similarity in sequence and structure of known targets.
Further profiling, determination of the timing of appearance of molecular components, and careful analysis of the localization of these components is required for the accurate construction and assignment of interactions to appropriate cell types or CNS regions (Fig. 4B).
The assignments of the interactions between the oxidizing gases, ozone and nitrogen dioxide, and the filtering material selected from the studies developed in Part I are established.
The anatomical toolbox yielded a 20% assignment of this interaction cluster (Fig. 3 D,E ) to left V4, with the remainder clearly extending more anteriorly, including into the left fusiform gyrus.
The assignment of pairwise interactions defined the spatial arrangement of channel amino acids with respect to the known inhibitor structure.
The use of spectroscopic methods, such as FTIR can bring valuable information about the mechanism of interaction, by the assignment of the bands that appear or disappear in the mixture's spectra, comparative to the ones for active substance and excipient.
Assignment ensembles for functional NMR studies : peaks with low SAR values can be exploited for the localization of dynamical zones or the localization of interaction interfaces, as shown with the assignment ensemble obtained on EIN (Fig. 5).
Despite this fragmentation of the NOE network, the assignment ensemble obtained by NOE net is sufficiently well restrained to allow the localization of interaction sites.
Level of interaction.
Given interaction data result in multiple assignments of genes to process units.
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