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Although this represents a promising approach, a recent meta-analysis of six biological assignment trials of almost 1200 patients found outcome data to be inconsistent because of the various conditioning regimens used, and any improvements in progression-free survival (PFS) and overall survival (OS) are frequently offset by the high allo SCT-associated TRM.
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A random assignment trial requires a control group that gets no aid, or maybe placebo aid, like sugar pills in medical trials.
We will perform a prospective biologic assignment trial to compare RIC alloHCT with nontransplant therapies based on donor availability.
The study was a prospective, quasi-experimental, random assignment, trial with patients serving as their own controls.
In a biologic assignment trial comparing patients who underwent tandem autotransplants to patients who underwent autotransplants followed by NSC as their initial therapy for myeloma, the 3-year DFS and OS was similar.
All models included BP trial assignment, glucose trial assignment, and presence or absence of cardiovascular events at baseline.
Intervention optimization designs such as fractional factorial and sequential multiple assignment research trials (SMART) are particularly valuable when the intervention development questions involve combinations or sequences of intervention components [18].
Sequential Multiple Assignment Randomized Trials (SMART), use experimental design principles to answer questions for building adaptive interventions including whether, how, or when to alter treatment intensity, type, or delivery.
A sequential multiple assignment randomized trial (SMART) is a novel trial design that can test these dynamic treatment regimens and lead to treatment guidelines that more closely mimic practice.
We developed a Phase 2 trial which is a small n sequential multiple assignment randomized trial (snSMART) design to test several treatments for a rare disease for which no standard therapy exists.
The Sodium Lowering in Dialysate (SoLID) trial is an ongoing a multi-center, prospective, randomised, single-blind (assessor), controlled, parallel assignment clinical trial, enrolling 96 home and self-care hemodialysis (HD) patients from 7 centers in New Zealand.
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