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The procedure of video-rating ensures the full 'blinding' of the Dutch raters of an individual's assignment to group.
In the Clark et al. [ 38, 39] studies sequential assignment to group treatment or to the wait list was performed on the basis of matching for sociodemographic variables.
Only after the recruiter determines a participant is eligible for the study, the participant agrees to participate and they are enrolled, will assignment to group be made by opening the next envelope in the sequence.
The randomization and assignment to group was performed by the senior researcher using a computer-generated random number list (EPI INFO 6.0; Centers for Disease Control and Prevention, Atlanta).
Of course our pilot study has the limitations of a small sample size, absence of a control group, and non-random assignment to group or individual use of the 'Taking Control' booklet.
After assignment to Group 1 and Group 2, patients were randomized by computer using a block randomization (six patients per block) to RUL 5, RUL 2.5, and bifrontal (BF) ECT in Group 1, and to RUL 5, and RUL 2.5 in Group 2. Assignment was concealed until administration of the first ECT treatment.
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Future studies with random assignment to groups are nevertheless required to investigate the causal connection more directly.
Control mice received no additional treatment after randomization and assignment to groups.
Assignment to groups was based on the generally accepted diagnostic protocol RDC/TMD.
Propensity score matching methodology has a strong statistical lineage in situations of nonrandom assignment to groups.
First, the quasi-experimental study design is subject to selection bias owing to nonrandom assignment to groups.
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