These assignments included all co-expression evidence, i.e., assignments supported by either yeast or human co-expression analysis, as well as those derived from clusters identified based on literature mining approach as discussed later.
To understand the composition of the NH spectrum, we performed 3D CαNH, 3D Cα(CO NH, 3D NHH, 2D CH, and 2D C(C H experiments (see section S3 for a detailed discussion of the assignments), supported by C- and N-chemical-shift data.
We calculated the percentage of cases in which Affymetrix gene assignment was supported by the GeneAnnot gene assignment.
Our assignment is supported by a theoretical model based on sixth-nearest neighbour tight-binding and a force-constant approach.
This assignment was supported by comparison with the product pattern obtained with the same construct but having the Ile70Ala mutation, which partially alleviated the arrest2.
This assignment is supported by the minor presence of an early pinaceous species (Pityites solmsii (Seward) Seward) within the Wealdon deposits [4].
This assignment was supported by H NMR analyses.
This assignment is supported by the ν NO of 1591 cm -1 reported for 6C ferrous P450 cam-NO.
This assignment was supported by subsequent Pronase digestion and ES-MS and ES-MS/MS identification of the sVSG221 glycopeptides (Supplementary Table SIV; Supplementary Figure S3A).
This assignment was supported by NOEs including C N 4 H2 → C N 4 H1, C N 4 H2 → C H5, C N 4 H1 → C H5, and C H5 → C H6.
This assignment is supported by H ENDOR data, presented in Figure S8, Supporting Information, which exhibits a strongly coupled doublet, exchangeable in D2O, with Amax = 12 MHz, characteristic of the hydroperoxy ligand.
