Our data provide the first evidence that assignment to region of origin is feasible in western Alaska despite low levels of divergence.
This fine-scale geographic differentiation enhanced assignment to region of origin, and through the identification of adaptive diversity, fundamentally changes how these populations should be conserved.
Were the data homogeneous, the assignment of regions, even if arbitrary, would not be expected to produce statistically significant differences among groups.
It should be noted that there is colonic excretion of this radiotracer that can render qualitative interpretation and assignment of regions of interest for SUV analysis difficult.
SNP detection and correct assignment to regions with segmental duplications is not trivial and hampered by paralogous sequence variations [ 26], duplicon SNPs and multisite variations [ 6].
Because CS used for the annotation contains many ambiguous nucleotides and insertion, instead of CDS extraction, homologous regions based on corresponding nucleotide sequences of CDS in H37Rv was determined to extract the corresponding regions in CS, with the assignment of each region based on the locus_tag (the Rv number) of CDS, repeat regions, rRNA and tRNA of H37Rv.
At the same time, the inferred evolutionary neighborhood is extended by the identification of an outgroup, leading to more precise taxonomic assignments, while regions without detectable taxonomic signal are instantly discarded.
The accuracy of assignment of control region sequences to the eight subclades was further supported by the grouping of control region haplotypes within haplogroups on a network and by the continuous geographic distribution of the subclades.
Instead of city schools filled with poor black and Hispanic kids separated from a burgeoning ring of suburban districts stocked with affluent whites (and in some places, Asians), one district controls student assignment for the region.
Linear matrix inequality (LMI) techniques are utilized combining pole region assignment with H-infinity constraints.
