Although TOF MS is commonly used in MSI, FTICR MS is preferred due to its superior mass resolution and mass accuracy, which allows unambiguous peak recognition and precise assignment of exact masses.
For this reason, the performance of the method cannot be effectively evaluated at protein level as the assignment of an exact result over a wrong one is uncertain, whenever a mix of correct and incorrect predictions is recovered for every protein.
The exact assignment of spectral components to a certain type of modes is difficult, especially that concerns stretching vibration range.
On the other hand, Figure 1b showing the plot Co/La, is able to solve some other deposits but the samples coming from the Flegrean Is. (except Procida Punta Lingua) and Sicily (except Vivara, Incaldana and Arivito) seems to show a same pattern making difficult an exact assignment of artefacts to such areas.
Whilst exact assignment of trace fossils to their makers is generally impossible, traces may for example provide the earliest physical evidence of the appearance of moderately complex animals (comparable to earthworms).
Both spots identified as VIP36 reside within these protein tracks confirming the exact assignment of the serum derived signals to the master secretome and to the preparative gel.
An exact assignment of the group level activations to individual early visual areas was not possible because of interindividual differences in the layout of the areas and in cortical folding.
Exact assignment of these putative rotifer genes to aquaporin family members was difficult because of relatively short sequence lengths and low percentage similarity to aquaporin genes already in the databases.
Note that an exact assignment of activated clusters to visual areas was not possible for group data due to interindividual differences in the layout of the areas and in cortical folding.
The present model, in contrast, uses purified, early-passage SFB with a phenotype similar to their in vivo status in the synovial membrane [ 15], allowing the exact assignment of the observed effects to SFB.
