Exact(8)
The potential confounding of treatment-related effects in RI studies by litter (i.e., genetic effects) has been raised, because the RI does not always randomize the assignment of animals to treatment groups but often "assigns litters to the same dose group and uses all animals, while keeping track of litter identification information" (Bucher 2002).
These involved the random assignment of animals to treatment groups; blinded assessment of how the animals fared; a record of animals removed from the results, and a calculation to show that the study had enough animals to be statistically sound.
A better model would fit a true mixture model by computing posterior estimates of assignment of animals to groups.
The study design, including the assignment of animals to a respective group, is explained in Figure 1a.
Tissues were evaluated using light microscopy by a veterinary pathologist blinded as to the assignment of animals to group or treatment.
Assignment of animals for MitoQ treatment was made in such a way that the animals of different experimental groups were age-matched during the study.
Similar(52)
Assignments of animal and fungal cyclins to orthologous groups were extracted from KEGG Orthology [ 24, 25].
From the toxicological perspective, the completely randomized (CR), litter-matched (LM) and nested (NE) designs correspond to the random assignment of individual animals, littermates, or entire litters to either a control or test group.
The pathologists were blinded to the assignment of the animals.
The assessment was conducted by two independent examiners (HN, TM), who were blinded to each other's findings and to the treatment group assignment of the animals.
Each section was assessed in a blinded manner by a pathologist who was unaware of the treatment group assignment of the animals.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com