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Nuclear grade is used as a major determinant of therapy for these patients, although assignment of a grade is a subjective evaluation and there is inconsistent evidence for prognostic importance [ 1- 11].
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This means that language that directs students to act in a particular way through pressure or a threat (e.g., assignment of a bad grade) should be avoided (Reeve, 2009).
Viewers primarily watched course lectures, solvers primarily handed in assignments for a grade, all-rounders suited in the middle of watching lectures and handing in assignment.
However, these systems present some limitations such as assignment of a single vascularity grading and coarse grading scales and are unable to describe blebs with mixed morphology.
Mis-assignments of grade I to grade III or vice versa are rarely reported, but grade II tumors usually show the lowest degree of concordance.
The assignment of a patient to a severity grade (Mild, Moderate, Severe) was based on the distribution of the sample for the corresponding measure (Table 1).
In this context, medulloblastomas in particular can be highly malignant, as evidenced by their assignment of WHO grade IV, but their overall, progression-free, and 5-year survival rates are comparable to those of ependymoma, and far exceed those of GBM [11][12][13].
In part this limitation may be attributable to the considerable interobserver variability in the assignment of Gleason grade [ 9].
A large series study, conducted on 575 women affected by EOC, optimally surgically debulked without macroscopic residual disease, showed that tumor cell type was both more reproducible and provided superior prognostic information compared with assignment of tumor grade [ 26, 27].
Likewise, concerning the results obtained when applying our gene signatures to the ICR cohort we noted that gene signatures could disagree for some tumors in the assignment of histologic grade 2 into grade 1-like or grade 3-like.
Several different guidelines have been proposed in the literature for assignment of nuclear grade [e.g. [ 2, 11]], however none of these allow incorporation of heterogeneity of grade which has been observed by others and by us [e.g. [ 11, 12, 22]], or mixed architecture [ 22].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com