Items requested for every patient were as follows: patient identification, date of surgery, eligibility, allocated treatment by random assignment, age, sex, primary tumour site, Dukes' stage, induction chemotherapy, dates of recurrence, death, or last visit.
The same data are plotted in Figs. 1 A and 2 A. The mean values in Table 2 were adjusted for glycemia treatment arm assignment, age, diabetes duration, sex, nonwhite race, insulin use, and systolic and diastolic blood pressure; the change in values were additionally adjusted for the time interval between visits (trial baseline to month 4, or trial close-out to postclose-out visit).
Subjects were randomly assigned to treatments by using a computer-based minimization procedure to balance assignment by age, sex, waist, and HDL cholesterol.
Current National Cancer Institute (NCI) criteria for risk assignment utilise age and white blood cell counts (WBC) at diagnosis to stratify patients into standard risk (SR; 1-9.99 1-9.99of age and WBC<50,000/μl) and high risk (HR; ≥ 10 years of age or WBC ≥ 50,000/μl) [ 4].
Intervention group assignment, younger age, and better baseline physical function and self-perceived health were independent predictors of long-term MacArthur battery score improvement.
These were "treatment assignment", "gender", "age", "baseline SPADI", "sick leave at baseline", "baseline pain medication", "duration of condition" and "previous shoulder problems".
In initial analyses we examined the interaction effects between intervention group assignment, sex, age, baseline weight, race/ethnicity, and weight loss in association with CVD risk factor changes.
However, the authors acknowledged several weaknesses in the study including a non-randomized study design (participants had the option to select their gum flavor which dictated their group assignment), average age of the maltitol group was higher which had a negative association with plaque MS levels, and only 59% of the control group remained in the final analysis.
To balance treatment assignments by age group, a permuted block randomization method was used to generate the treatment randomization within age groups.
At baseline risk assignment, their median age was 44 years, 311 (17%) of them reported a prior breast biopsy, and 388 (21%) were Hispanic.
Eligible patients are randomly assigned via a website to either the telemonitoring group or the usual care group by using a minimisation method with biased-coin assignment balancing on age (≥65 vs <65 years), left-ventricular ejection fraction (LVEF) (≥30% vs <30%), and having a history of ischaemic heart disease (IHD; IHD vs non-IHD).
