The phrase "assigning rare" is not correct and does not convey a clear meaning in written English.
It may be intended to refer to the act of designating something as rare, but without additional context, it is unclear how to use it appropriately.
Example: "The process of assigning rare attributes to the collectibles was meticulous."
Alternatives: "designating as rare" or "classifying as rare."
Therefore, we have developed a cutoff-independent approach to assign rare codons by comparing the observed codon composition of one column to all possible, alternative combinations of synonymous codons.
We can disentangle these two hard sweeps by assigning the rare haplotypes to either of the two founding haplotypes if they differ from the latter by only one mutation.
We found 27 CNVs present in <1% of subjects which were assigned as rare, 13 CNVs were found only in Amish family 884, and were therefore designated "Amish-specific" or "private" CNVs.
Using different values of f allows the relative weight assigned to rare variants to be varied.
Therefore, we developed a new, cutoff independent approach to assign critical rare codons which compares the observed codon composition of one column in a multisequence alignment to all possible, alternative combinations of synonymous codons.
In conclusion, our study indicates that in silico evaluation is insufficient when assigning pathogenicity to rare nonsynonymous variants and demonstrates the need for both family and multi-tiered functional studies, even when dealing with previously reported "pathogenic" mutations.
Those who saw the film assigned it a rare average grade of F, according to market research firm CinemaScore.
But examples of conventional white-collar offices where no one has an assigned desk are rare enough in the U.S. that CBRE had to look to its outposts in Europe for ideas.
Therefore, a common haplotype is more likely falsely assigned than a rare haplotype.
Methods to phase rare variants are being developed, 5 and as more sequence data becomes available then LD relationships between variants will become better understood, and it may be possible to assign even quite rare variants to known haplotypes.
