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For the Pageman functional annotation, a complex system of automated functional annotation and manual curating was involved in assigning function to the rice genes (details are described in [ 27]).
This has resulted in substantial research efforts in assigning function to all identified open reading frames – referred to as functional genomics.
Nishizaki, S. S. & Boyle, A. P. Mining the unknown: assigning function to noncoding single nucleotide polymorphisms.
Another area I specialize in is assigning function to the various domains of individual proteins and prioritizing drug development against the most promising targets.
The complete sequencing of rice genome achieved in year 2005 (International Rice Genome Sequencing Project[2005]), has brought biological research to the genome scale and post-genome era, while assigning function to every rice gene is still an enormous challenge.
Beyond evolutionary biology, understanding of domain evolution has a role in assigning function to a rapidly increasing body of data associated with proteomics.
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It consists first of finding the genes -- no easy task since their sequences occupy a mere 3percentt of the DNA in the genome -- and then of assigning functions to the genes.
Assigning functions to proteins hold key to understand the molecular mechanism of life.
Reliable methods for assigning functions to uncharacterized proteins are required to support and supplement these methods.
One step towards assigning functions to these putative ncRNAs is to consider RNA interactions.
The quality of automatic methods for assigning functions to uncharacterized proteins is extensively discussed (11).
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