Noonan syndrome has similar clinical manifestation with TS [ 13] and there are only two cases with Noonan syndrome in this study, so they were assigned into category of TS.
Although tremendous progress has been made through the application of such systematic studies, we found that within the S. meliloti proteome 3,376 (54%) proteins were not assigned to a functional category according to COGs, 290 (5%) have been assigned category S (function unknown), and a further 307 (5%) proteins have only been assigned into category 'R'generalral function prediction').
The groups are assigned into two categories: those that appear only in one sample class or the other and those that appear in both.
Percentage cover of substrate (abiotic) was assigned into three categories: hardbottom (consolidated carbonate substrate), rubble (unconsolidated material of <0.5 m diameter), and sand (>0.5 cm thick layer).
The patients were subsequently assigned into risk categories using established criteria.
Cases were assigned into deprivation categories using super-output areas, which are based on the postcode of residence.
Drugs are further assigned into MoA categories according to the OWL constructs and axioms defined in the FTC.
Among the 1,924 Group I genes, only 876 genes (46%) were annotated and could be assigned into functional categories.
The gene families were assigned into functional categories based on the Clusters of Orthologous Groups of proteins (COG) database (Tatusov et al. 2000).
Most of the unigenes were assigned into several categories, including stress response, defense response, multi-organism process, pathogenesis, extracellular region, nutrient reservoir activity, enzyme inhibitor activity, antioxidant activity and oxidoreductase activity.
