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Each QTL was assigned an effect that was drawn from a Gamma distribution with shape parameter 0.4 and inverse scale parameter 1.66, following Hayes and Goddard [ 7].
Two hundreds SNPs with MAF 10 15% were randomly selected to be causal SNPs; these causal SNPs were assigned an effect size, or log odds ratio, drawn from a uniform distribution U [0.1, 0.5].
Two hundreds SNPs with MAF 10 15% were randomly selected to be causal SNPs; these causal SNPs were assigned an effect size drawn from a uniform distribution U [0.05, 0.1].
For each real dataset, we picked at random one or two SNPs as QTL (the same for each replicate within each scenario but not across scenarios) and assigned an effect (the same for each replicate; the effect could be additive or dominant).
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A simulation study based on a granddaughter design was conducted, and QTL were assumed, either by assigning an effect independent of the environment or as a linear function of a simulated environmental gradient.
MBONs grouped by square brackets represent cases where the available set of driver lines do not allow assigning an effect to a single cell type, but only to the bracketed set.
MBONs grouped by square brackets represent cases where the available set of driver lines do not allow assigning an effect to a single cell type, but only to that set of MBONs.
Simulated QTL were assigned an additive effect inversely proportional to the standard deviation of the allelic state in order to standardize the amount of genetic variance attributed to QTL with different MAF.
In PD patients, decreased activity in the γ-band and increased activity in the β-band during movement execution has been assigned an antikinetic effect (Brown and Marsden 1998; Schnitzler and Gross 2005).
Based on the AHP results, each factor was assigned a percentage effect on the design of the roadways' support and their stability.
As it has been described, each SNP gives rise to two different genotypes with phenotype consequences, and we assigned a binary effect to each SNP.
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