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In this paper, we have shown that the CSIDOP method can not only provide additional functions to the incomplete GO annotations, but also assign functions for 181 human proteins that currently do not have GO functional terms.
Overall, we could assign functions for 618 H. sapiens proteins from PPIs with common domain patterns in the lookup table.
Hayete and Bienkowska [ 34] designed an automated predictor based on decision tree to assign functions for domains.
We were able to assign functions for 3,075 of the 9,623 repetitive elements, based on homology search against the NT database, leaving 6,548 ~68.055%) repetitive elements functionally unassigned.
Here, we use P. berghei to systematically analyze the entire Plasmodium protein phosphatome and, where possible, assign functions for each PP throughout the life cycle in vivo, including during mosquito transmission.
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We used GO 'molecular function' terms (Ashburner et al., 2000) to assign function for each protein in our dataset.
Despite the plethora of available sequences and structures, START domain structure/sequence alone remains insufficient to assign function for newly discovered family members.
These debates accept intelligence services as an integral and "normal" part of the democratic state mechanisms, performing various assigned functions for the defense and protection of democracy, regulated by legislation, financed by public funds and providing a service for the community at large like any other governmental department.
Details of assigned functions for each of the 10 Neisseriaceae strains are listed in Supplementary Table S3.
These functions represented either missing enzymatic activities, for which no ORFs had been previously identified, or previously assigned functions, for which additional isogenes were discovered.
It thus provides promises for assigning functions for genes where a biochemical activity of the gene product cannot be predicted based on sequence homologies to other known proteins.
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