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Reverse genomics consists of identifying a specific sequence, either coding or non-coding, and try to assign a function using sequence comparison or functional analysis.
The emergence of RNA interference (RNAi) on the heels of the successful completion of the Drosophila genome project was seen by many as the ace in functional genomics: Its application would quickly assign a function to all genes in this organism and help delineate the complex web of interactions or networks linking them at the systemic level.
Hence, beyond the information given by the sequence, or even the location of the protein, functional studies are crucial to clearly assign a function and a name to each individual SNARE.
In silico functional annotation based on protein signatures and homologies allowed us to assign a function to 43% of the 11,839 predicted proteins.
You can assign a function to the Shortcut button, which is one of the Zen's handiest features.
Of these 215 genes, an E > 10−10 was used to assign a function for 205 genes, and a value in the range of 10−7 to 10−10 had to be used to assign a function for about 10 genes.
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Each of the three applications may aid in assigning a function and in classification of binding patterns.
We investigate the totally geodesic Radon transform which assigns a function to its integration over totally geodesic symmetric submanifolds in Riemannian symmetric spaces of noncompact type.
Prior to the release of the sequence, only a few genes were assigned a function each year.
Of the 2,122 CDS, 1,387 (65%) were assigned a function through sequence analysis.
Again, a huge proportion of proteins (10 out of 26) has not been assigned a function yet.
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