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Safety assessments were evaluated using the Safety Set (SS; all patients who received at least one dose of lacosamide).
Efficacy assessments were evaluated using the FAS (patients who completed the Titration Phase and started withdrawing background AEDs).
Agreements between depression diagnosis and DSM, PCI, and self-reported assessments were evaluated using Cohen's kappa coefficient.
Health outcome assessments were evaluated using the EuroQol-5D (EQ-5D) questionnaire at randomisation and on Day 84.
Pain and physicians' and patients' global assessments were evaluated using a 100-point visual analog scale, where 0 indicated excellent well-being and 100 indicated feeling extremely unwell.
The assessments were evaluated using the nine GHC indicators that correspond to health resources availability assessments (out of a total of 26 indicators), based on whether they were capable of collecting the necessary data for calculating each of the indicators.
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Study methodological assessment was evaluated using the PEDro score.
Ecotoxicological risk assessment was evaluated using risk quotients (RQs) for sludge-amended soil.
Quality assessment was evaluated using mthe odified Jadad score [ 18].
Cognitive assessment was evaluated using the Telephone Interview to Assess Cognitive Status (TICS) [ 30].
Cognitive assessment was evaluated using the Telephone Interview to Assess Cognitive Status [TICS; [ 29]], as well as delayed word recall.
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