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Secondary objectives include assessments of response data, duration of response, quality of life, pain intensity, analgesic consumption, and assessment of pharmacokinetic/pharmacodynamic relationships for eribulin.
Assessments of response were made prior to commencing therapy and repeated 2 monthly.
Assessments of response rates are performed and adjustments made if needed.
One patient was not evaluable for efficacy because study treatment was discontinued without any postbaseline assessments of response.
In addition to these categorised assessments of response, lesion sizes alone may also be studied by bi-dimensional or three-dimensional measurements.
There was no difference with intervention or placebo in those with severe knee OA, either group when assessed with the WOMAC questionnaire for assessment of pain, function, and joint stiffness, or patients' assessments of response.
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An accurate assessment of response rate was difficult to assess for all recruitment pathways.
Assessment of response in treatment trials should ideally encompass the prior trajectory of change before treatment.
Personalized treatment of multiple sclerosis (MS) depends on prognostication at baseline, a shared treatment decision between the physician and patient, and early assessment of response to therapy.
Alpha-fetoprotein (AFP) levels were measured every 8 weeks in all patients throughout the study, but changes in AFP were not an end point for assessment of response.
Two of these measures are the Computerized Assessment of Response Bias-97 (CARB-97) and Word Memory Test (WMT).
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