For other outcomes like the assessment of refusal skills, validity of self-report data might be limited by restricted accessibility, that is, whether adolescents are really able to judge their own competence to resist cigarette offers.
On both farms, during the whole experimental period, the amount of TMR was weighed and on the basis of visual every day assessment of feed refusal, average DMI of the feeding group including experimental cows during the glucose tolerance test (GTT) was estimated per week.
Exclusion criteria were comorbidity with major disorders of the central nervous system (e.g., Parkinson's disease, dementia, epilepsy), delirium and any condition affecting the patient's ability to complete the assessment, including refusal of informed consent.
Exclusion criteria were comorbidity with major disorders of the central nervous system (e.g., Parkinson disease, dementia, epilepsy), delirium and/or any condition affecting the patient's ability to complete the assessment, including refusal of informed consent.
A detailed assessment of reasons for refusal will be described separately; in general, older women and women with lower household income were least likely to participate.
Of 33 patients enrolled, 7 were not evaluable for treatment anti-tumour effect: 4 patients with no VNR infusion and 3 others having stopped treatment before first assessment of response (1 refusal, 1 major protocol violation and 1 toxicity).
The limitations of our study were a cross-sectional design, moderate sample size, high rate of refusal to participate in the study, and non-assessment of other psychotropic drugs except antipsychotics.
Among the strengths of the study, besides sample size, are the low rates of refusal and loss to follow-up, and the prospective cohort design that allows assessment of temporal relationships.
In case of refusal, only age and socio-economic status were documented along with the key reason(s) for refusal.
The aim of this survey was to quantify refusal rates and identify factors of refusal pertaining to studies and recruiting pediatricians in the research recruitment process.
