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Details of the assessments are summarised in Table 1.
The overall results of the assessments are summarised in Table 2.
A total of 161 patients were treated in this study (84 with remifentanil, 37 with fentanyl and 40 with morphine); patient characteristics and baseline clinical assessments are summarised in Table 2.
Changes over time in HRQoL assessments are summarised in table 3. Improvements based on the ASQoL were substantial and statistically significant compared with placebo by week 24 and steadily improved over time.
All other carer assessments are summarised in table 2. If the patient dies, carers will be interviewed in a place of their choice at 7 months post-bereavement to consider complicated grief which requires 6 months of symptoms, using the Inventory for Complicated Grief.
The timing and content of study assessments are summarised in Table 5. Frequency and purpose of system use of QC are determined from automatically generated computer logs used to record details of each search including the search filter chosen, keywords entered, data sources accessed, user IP (Internet Protocol) address, date, time and duration of searches [see Additional file 4].
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Performance of typically developing children and children with DS on the card-reaching task, and the speech and language assessments is summarised in Table 1.
The parameters important for pre-TAVR assessment are summarised in Table 6.
The results of the indicator-based sustainability assessment are summarised in Table 5.
The results of the critical assessment are summarised in table 4. The three studies did not state explicitly the viewpoint for the analysis (e.g. a specific provider or providing institution, the patient or groups of patients, a third-party payer, or society).
The results of this assessment are summarised in Table 1.
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