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Services (reception area, clinician's consultation, HIV counselling, pharmacy, nutrition counselling and social worker's assessment) were assessed against performance standards that apply to all clinics.
At clinic visits prior to each infusion and at follow-up, the following were performed: a count of tenderness and swelling of 68 joints; the number of flares experienced by patients or assessed by study personnel were recorded; patient and physician global assessment were assessed on a visual activity scale; and functional status was assessed by Health Assessment Questionnaire HAQQ).
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Its robustness, which is essential to support successful comparative assessment, is assessed using synthetic data and validated using experimental data.
Inter-rater agreement (ADE vs control group, 3 causality assessment methods and preventability assessment) was assessed with the kappa test [31].
The overall mean time to neurological assessment was assessed as a secondary end point.
This can be attributed to the retrospective nature of our study, where OSA assessment was assessed only by patient history.
Currently, tumour cell percentage assessment is assessed using heamatoxilin-eosine (H/E) stained specimen for histopathological review.
Duration of assessment was assessed automatically on Octopus perimetry and manually using a stopwatch for Goldmann perimetry.
Pain location, frequency, duration and intensity assessment was assessed with the Nordic Questionnaire which has demonstrated reliability and validity [ 136], with modifications based on subsequent research [ 137– 137].
The impact of the system on the completeness of assessment was assessed using generalized estimating equations with an exchangeable correlation matrix to account for the clustering by clinics.
Inter-observer reliability of lung sound assessment was assessed using Fleiss' kappa, which is a generalization of Cohen's kappa to multiple raters that provides a conservative measure of agreement.
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