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In general, MXF treatment was very well tolerated, with physician's overall assessment of tolerability as "good" or "very good" in 95.2% (n = 10,834/11,377) of patients.
The global assessment of tolerability expressed by the patient is shown in Table 4.
The Wilcoxon signed rank test was used to analyse the global assessment of tolerability expressed by patients.
It is not a chance that a good evaluation in the global assessment of tolerability expressed by the patient was lower after PLA than after active drugs.
A global assessment of tolerability was expressed by the patient, using a 5-point Verbal Rating Scale (VRS: 'excellent', 'very good', 'good', 'sufficient' and 'poor').
The investigator reviewed the completed diary with the patient to ensure that all required information had been registered, recorded vital signs and concomitant treatments and expressed a global assessment of tolerability.
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Patient and physician global assessments of tolerability were made at the end of the study (rated as very good, good, moderate, poor, or very poor).
Patient global assessments of tolerability were similar (P = 0.415) for both study groups: 94.0% of patients in the valsartan group and 92.7% in the placebo group rated treatment as very good or good.
Body weight changes were also monitored in the xenograft mouse efficacy study in order to give a crude assessment of formulation tolerability (Figure 8).
Large animal models have been proposed to improve assessment of safety, tolerability and especially to increase translational reliability of efficacy signals obtained in preclinical studies.
Assessment of biological tolerability was performed at baseline and at end of treatment using clinical laboratory tests.
More suggestions(16)
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