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Assessment of the sections was performed 'blind' by two investigators.
A quantitative histomorphometric assessment of the sections stained with Safranin O was performed using the Mankin scoring system.
Microscopic histopathological assessment of the sections indicated that the mammary tumours that developed in the parous MMTV-c-myc study mice were cribiform glandular adenocarcinomas as previously described for MMTV-c- myc mammary tumours (Cardiff et al, 2000).
Assessment of the sections at high magnification and correlation with serial sections stained only by H&E, revealed that the S100A7/psoriasin expression was usually confined to a subset of epithelial tumor cells that showed morphological features of squamous differentiation.
As seen in mammary tumor tissues, a strong but focal signal was observed in some samples and assessment of the sections at high magnification revealed that the mouse S100A7/psoriasin expression was confined to a subset of epithelial cells surrounding hair shafts consistent with the localization of human psoriasin/S100A7 in normal human skin [ 3].
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After quality assessment of the sectioning and staining, each bin of samples was returned to the laboratory at Public Health England.
Bottom: concrete quality assessment of the surveyed sections of a bridge deck in Figure 18 (Bottom).
Figure 19 Top: delamination assessment of the surveyed sections of a bridge deck in Figure 18 (Top).
The assessment of the entire sections was made, including the possibly occurring myositis areas.
Clinically, the severity of OA is usually graded in accordance with the morphological changes of the cartilage surface (such as degree of roughness and fibrillation) and the histopathological assessment of the tissue sections [ 15, 21].
Most of the evaluators participated in the consensus meeting where a joint assessment of the stained sections under a multi-headed microscope and the previous results obtained from the assessors were scrutinized.
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