Sentence examples for assessment of the binding from inspiring English sources

This probe indirectly allows the quantitative assessment of the binding of fibrinogen to erythrocytes, based on the changes on the cell membrane potential arising from the fibrinogen binding.

Collectively, our findings represent the first quantitative assessment of the binding interaction, and binding thermodynamics, of a physiologically relevant complex involving the oncoprotein gankyrin.

In 97 cases out of a series of 102 cytosols, assessment of the binding parameters of [H]oestradiol (multipoint Scatchard plot analysis) gave Kd values of the same order of magnitude for both assays (median Kd values of 0.30 for DCC and 0.40 nmol/l for hydroxylapatite; Table 1).

Assessment of the binding affinities of isoflavonoids for ER and subsequent effects on uterine growth suggest these compounds are less active estrogens than estradiol and therefore may reduce the risk of developing breast or prostate cancer in humans by preventing estradiol binding to ER.

As an initial assessment of the binding interactions of POG-Tβγ-OMe, we performed UV-stimulated affinity labeling experiments with doubly modified βγ in solution in the presence or absence of Tα-GDP, and the UV-cross-linked product was immunoblotted with anti-Tγ antibody.

For such glycan arrays, HA cleavage by protease treatments was not required for assessments of the binding abilities of HA (Stevens et al. 2006; Kumari et al. 2007).

We recently reported detailed in vitro comparative assessments of the binding affinity of insulin, X10 and IGF-I for IR isoforms and IR/IGF-IR hybrids, while simultaneously performing cancer-relevant signalling pathway analyses (e.g. pAkt) and direct mitogenic assays in a mammary epithelial cell line (19).

While assessment of the MPEP binding site offers insight into the binding kinetics of mGluR5 drugs that target this site, it must be noted that there is a family of mGluR5 allosteric modulators that do not bind to this site [ 27- 29], and currently there are no radioligands available to directly assess the density and affinity of these non-MPEP sites.

While using binding data from 2 and 3 have yielded more acceptable binding values for 1 and a reasonable assessment of the 1·HSO4 – binding conformation, discrepancies with other complexes indicate that either more complicated equilibria are present or that cooperativity cannot be neglected in these systems.

Statistical analysis was performed by Graphpad Prism 5. Assessment of the relative binding revealed that 86% (69/80) and 99% (79/80) of the plasma were able to reach an IC50 binding titer with V3B peptide and V3C peptides respectively; with substantially low antibody titers that bind to V3B than V3C (mean IC50, V3B=2736 versus V3C=12612) (p<0.0001).

In agreement with experimental results, the assessment of the theoretical binding of compounds 1 7 to galectin-3 by MM/PBSA method displayed higher affinities for compounds 3 (−9.7 kcal/mol) and 5 (−11.1 kcal/mol).