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In view that all antimuscarinics show similar efficacy, the assessment of side effects alone suffices to provide the required information for decision-making and evidence grading.
This plan will also enable better long-term assessment of side effects.
Patients were followed for further 12 weeks to continue assessment of side effects.
30 Previous studies often did not comprise long term outcomes and systematic assessment of side effects.
Furthermore, assessment of side effects will take place during these visits and migration and death will be noted.
5 30 31 32 33 Long term outcomes and assessment of side effects are missing in most studies and the clinical relevance of the reported effects is questionable.
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Regulators said that the combination of tests will provide a more accurate assessment of side-impact protection.
Ascertainment bias would be also possible in the assessment of side-effects, due to the known association between misoprostol and shivering and other prostaglandin-related clinical events.
For assessment of side-population, cells were stained with Hoechst 33342 (5 μg ml−1) at 37 °C for 90 min with or without reserpine (10 μ M, as a negative control; Sigma-Aldrich, Dorset, UK), washed and re-suspended in PBS.
Unlike the Bangladesh study (4 ), the Karakalpakstan study used moxifloxacin instead of gatifloxacin and included scheduled electrocardiograms (ECGs) and graded assessments of side effects to monitor for safety, including cardiac toxicity.
Based on pilot testing, which revealed poor trunk and head stabilization in sitting and side lying during the assessment of isometric side bending strength, this outcome was assessed in supine.
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